Shahenda Ramadan
Doctoral Student at the Max Planck Institute of Colloids and Interfaces
About
Ramadan is an International Max Planck Research School (IMPRS) doctoral student in the the Dimova Lab at the Max Planck Institute of Colloids and Interfaces.
Current research
Ramadan employs semi-synthetic strategies involving the expression of proteins and chemo selective attachment of synthetic GPI glycolipids to obtain well-defined GPI-APs (e.g., CD59 and Thy-1). She use these proteins to investigate the properties and behaviour of GPI-APs and their interaction with other proteins on model membranes. To achieve this, she inserts GPI alone and GPI-anchored proteins into lipid vesicles of different composition and size. She then uses Surface Plasmon Resonance (SPR) and fluorescence microscopy techniques such as Fluorescence Resonance Energy Transfer (FRET) and Fluorescence Correlation Spectroscopy (FCS) to study the effect of GPI-APs on model membranes and to quantify their interactions with other proteins.
Future research vision
With the knowledge Ramadan gained in drug delivery and protein research from her masters and doctoral studies, she will shift focus to active drug targeting in the future.
Key publications

Ramadan, S. Fusogenic proteoliposomes for the delivery of functional transmembrane ion channels; a possible approach for the treatment of channelopathies. International Journal of Biological Macromolecules, 2019.

Tammam, S. Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2. Journal of Controlled Release, 2021.

Key awards

Master's scholarship, Deutscher Akademischer Austauschdienst (DAAD).