Reem Hamed
PhD Student at the University of Paris
About
Hamed is a PhD Student in the Institute for Integrative Biology of the Cell at the University of Paris. She holds a master's degree in genomics and epigenetics from the University of Paris
Current research
Most data concerning inflammatory gene expression in senescence comes from studies of a small number of established human fibroblast cell lines derived from embryonic lungs or foetal foreskins. All of these fibroblasts express high levels of inflammatory genes in senescence induced by DNA damage. The regulation of inflammatory gene expression in senescence involves several signaling pathways and transcription factors, but we are far from having an exhaustive understanding of these pathways. The goal of Hamed's research is to determine whether high-level expression of inflammatory gene expression factors is a frequent or rare phenotype of senescent human fibroblasts using RNA sequencing, and to compare the transcriptomes of fibroblasts expressing inflammatory genes in order to identify the regulatory factors that determine their phenotypic differences.
Future research vision
RNAs an play important role in many complex gene regulatory pathways implicated in neuroplasticity, tumour development and cancer. Dysfunctional transcription factors or modifications to DNA methylation patterns are considered a critical alteration of gene regulation. Hamed's future research aims to better study those processes by integrating epigenetics, genomics and bioinformatics.
Key publications

Hamed, R et al. Optimization of DNA Extraction from Avian Blood. The FASEB Journal, 2021.

Daanaa, A et al. A Compatible Vegan Feedstock for Preparation of Plant-Based Culture Media and Production of Value-Added Biomass of Rhizobia. Sustainability, 2020.

Key awards

Master’s Scholarship, Université Paris-Saclay.

First Place, International BioDiversity Informatics Hackathon.

Second Position, Science Operation Leaders in Egypt (SOLE) competition.

Al Idrisi Master's Scholarship, Erasmus Mundus.