Dr Ola Sabet
Principal Investigator at the Children's Cancer Hospital (Egypt) and Senior Research Scientist at the Children Hospital (Zurich)
Dr Ola Sabet
Dr Ola Sabet
About
Sabet is a Principal Investigator at the Children's Cancer Hospital (Egypt) and Senior Research Scientist at the Children Hospital (Zurich). She holds a PhD in systems biology from the Max Planck Institute for Molecular Physiology.
Current research
Sabet's group is interested in understanding and deriving basic “systems properties” such as relationship between cells, interconnectivity, causality, and response to perturbation. With this regard, Sabet believes that breakthroughs in biomedical research can only happen if scientists are empowered with tools that allow them to “see” life. Microscopy-based techniques and quantitative methods based on advanced computer vision and data-driven modelling will be the primary approach to systematically map the spatial localization, temporal dynamics and activity profiles of proteins and nucleic acids within and across thousands of single cells.
Future research vision
Sabet's group focus lies primarily in paediatric diseases and the interplay between the body’s immune system and its ability to fight cancer (Immuno-oncology). They are also interested in immune disorders that can clinically manifest in the form of increased susceptibility to infections, malignant diseases, or an immune dysregulation. To achieve this, they will focus on high-dimensional investigation of cellular organization from molecules to tissues, developing new imaging tools and image analysis workflows, mapping the tumour immune microenvironment and studying the pathomechanisms of immunodeficiencies.
Key publications

Liu, P et al. Mathematical Foundation of Sparsity-Based Multiillumination Super-Resolution. arXiv, 2022.

Stallaert, W et al. Contact Inhibitory Eph Signaling Decouples EGFR Activity from Vesicular Recycling to Generate Contextual Plasticity. Science Signaling, 2018.

Masip, ME et al. Reversible Cryo-Arrest for Imaging Molecules in Living Cells at High Spatial Resolution. Nature Methods, 2016.

Sabet, O et al Ubiquitination Switches EphA2 Vesicular Traffic from a Continuous Safeguard to a Finite Signaling Mode. Nature Communications, 2015.

Schaupp, A et al. Composition of EphB2 Clusters Determines Strength of Cellular Response. Journal of Cell Biology, 2014.

Key awards

University Research Priority Program (URPP) ITINERARE, University of Zurich.

PhD Fellowship, Marie Skłodowska-Curie Actions.

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