Mohamed is a professor at the American University in Cairo (AUC) and senior fellow for the Global Brain Health Institute (GBHI) He established the Egyptian Network for Neurodegenerative Diseases (ENND) in 2013 and the Egyptian Dementia Registry in 2023 as platforms to study diseases determinants. Currently, he is leading the NIH funded, Egyptian Survey of Healthy Aging (AL-SEHA) to study Egyptian seniors to identify determinants of healthy aging. Additionally, Funded by the Davos Alzheimer’s Collaborative (DAC), Dr. Salama is leading the North African Dementia Registry (NADR). He is also leading the Health and Wellbeing across Lifespan (HWLS) strategic research program within the African Populations Cohorts Consortium (APCC). Most recently, Mohamed has been a steering committee member to serve the task for Brain Health in Africa. a pan-African initiative dedicated to advancing bold, coordinated action on brain health. and building on this, he is also a member of Nature Medicine Commission on Brain Health for Economic Resilience. Mohamed’s work focuses on studying determinants that can affect brain health across lifespan. Applying this exposome holistic approach on longitudinal cohorts to study external exposure X internal body response that shape brain health. This approach will assure having real time indicators of environment body interactions that can affect brain functions and identify early predictors of brain damage that could appear earlier than clinical signs allowing for early intervention.