Dr Mohamed ElGhazaly
Postdoctoral Research Fellow at the University of Sheffield
Dr Mohamed ElGhazaly
Dr Mohamed ElGhazaly
About
ElGhazaly is a postdoctoral research fellow at the University of Sheffield. He holds a PhD in biomedical sciences from the University of Sheffield.
Current research
The aged populations are generally more susceptible to infections. ElGhazaly's work uncovers methods by which a bacterium, known as Salmonella can promote premature ageing (senescence) within our cells in order to manipulate the host and establish infections. Aged cells tend to secrete an unusual profile of proteins depending on the stress. In his project, he examines the typhoid toxin, which is secreted by Salmonella Typhi to induce senescence. The project highlights how one bacterium, using one virulence factor can modulate our tissue microenvironment to establish an deadly infection.
Future research vision
ElGhazaly is very interested in ageing research. Ageing is not currently recognised as a disease, although it underlies many pathologies, including Alzheimer's, cardiovascular diseases, and infections. Whilst a lot of people would like to achieve immortality, the main priority in ageing research is to extend healthy lifespan - i.e. reach an old age without the suffering of many diseases. ElGhazaly would like to establish his career in ageing research in order to understand how we can promote healthy ageing.
Key publications

ElGhazaly, M et al. Typhoid Toxin Hijacks Wnt5a to Potentiate TGFβ-Mediated Senescence and Salmonella Infections. BioRxiv, 2022.

Humphreys, D et al. Senescence and Host-Pathogen Interactions. Cells, 2020.

Ibler, AEM et al. Typhoid Toxin Exhausts the RPA Response to DNA Replication Stress Driving Senescence and Salmonella Infection. Nature Communications, 2019.

Key awards

First Talk Prize, young International Cell Senescence Association (yICSA) conference.

First Poster Prize, Scientistt.com.

First 3-minute Thesis Talk Prize, University of Sheffield.

Outstanding Poster Presentation, University of Sheffield.

First Poster Prize, Cellular Microbiology Meeting at the Francis Crick Institute.

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