Dr Dina ElHarouni
Postdoctoral Research Fellow at Harvard University
Dr Dina ElHarouni
Dr Dina ElHarouni
About
ElHarouni is a research fellow in the clinical bioinformatics department of the German Cancer Research Centre (DKFZ). She completed her PhD at Heidelberg University and the DKFZ graduate school.
Current research
ElHarouni is part of the INFORM (INdividualized Therapy FOr Relapsed Malignancies in Childhood) drug screening platform, COMPASS (Clinical implementation Of Multidimensional PhenotypicAl drug SenSitivities in paediatric precision oncology) consortium, and the UNITE Glioblastoma project. Her research focuses on developing translational clinical quantitative scoring in drug response profiling and identifying key clinical biomarkers using multi-omics data integration.
Future research vision
ElHarouni will continue her research career in the area of precision medicine, combining AI, patient-derived models and clinical metadata. She aims to develop intelligent decision-making systems that can be applied across several molecular board setups and precision programs. She would also like to establish a comprehensive atlas of patient profile responses to bridge the gap between in-vivo and ex-vivo omics and therapeutic profiles, to dissect complex biological processes using interaction networks in a temporal manner.
Key publications

ElHarouni, D et al. iTReX: Interactive exploration of mono- and combination therapy dose response profiling data. Pharmacological Research, 2022.  

Gatzweiler, C et al. Functional therapeutic target validation using pediatric zebrafish xenograft models. Cancers, 2022.

Berker, Y et al. Patient-by-Patient Deep Transfer Learning forDrug-Response Profiling Using Confocal Fluorescence Microscopy of Pediatric Patient-Derived Tumor-Cell Spheroids. IEEE Transactions on medical imaging, 2022.

D ElHarouni, D et al. A pharmacogenetic study of VDR fok1 and TYMS polymorphisms and their association with glucocorticoid-induced osteonecrosis in Egyptian children with acute lymphoblastic leukemia. Frontiers in Oncology, 2018.

Adwan, H et al. Early Metastasis in Colorectal Cancer Poses an Option for New Diagnostic and Treatment Strategies. Cancer Metastasis, 2018.

Key awards

COMPASS EraPerMed Fund.

UNITEglioblastoma fellowship, Spezialforschungsbereiche Fund.

Erasmus Summer Program Fellow, Rotterdam Medical Center.

Presidential Leadership Program Fellow, National Training Academy (Egypt).

Youth Olympic Games Quota (10m air rifle shooting), International Olympic Committee.

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