Amr Saadeldin
a PhD candidate in the Disease Models, Development and Therapeutics Graduate Program
Amr Saadeldin
Amr Saadeldin
About
Amr Saadeldein is a PhD candidate in the Disease Models, Development and Therapeutics Graduate Program at Baylor College of Medicine, Houston, Texas, where he is supported by The Cancer Prevention and Research Institute of Texas Pre-Doctoral Fellowship. His research sits at the intersection of cancer neuroscience, computational genomics, and pediatric oncology. With a background spanning molecular medicine, bioinformatics, and gene therapy manufacturing, Saadeldin brings a multidisciplinary perspective to understanding the molecular basis of childhood brain tumors.
Current research
Saadeldin's research focuses on understanding how chromosomal aberrations drive the development of pediatric brain tumors, with a particular emphasis on medulloblastoma and ependymoma. He applies advanced computational modeling and single-cell and spatial genomics approaches to dissect the molecular and cellular mechanisms underlying these devastating diseases — two of the most common and aggressive malignant brain tumors in children. His work integrates multi-omic datasets to reveal how large-scale genomic instability reshapes the tumor microenvironment and influences cell identity during brain development.
Future research vision
Saadeldin aims to push the boundaries of pediatric brain tumor research through the application of cutting-edge sequencing technologies, including spatial transcriptomics, and 3D genomics. His vision is to build a comprehensive, high-resolution map of chromosomal aberrations and their downstream consequences at the single-cell level, ultimately identifying novel therapeutic vulnerabilities in medulloblastoma and ependymoma. By bridging computational biology with experimental cancer neuroscience, he seeks to translate these discoveries into precision medicine strategies for children with brain tumors.
Key publications

Zhang J, Ong W, Rasnitsyn A, Gonzalez RD, ..., Saadeldein A, ..., Taylor MD et al. Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma. Nature, 2026. https://www.nature.com/articles/s41586-026-10264-6 

Gad, A.Z., Morris, J.S., Godret-Miertschin, L., Montalvo, M.J., Kerr, S.S., Berger, H., Lee, J.C., Saadeldin, A.M., Abu-Arja, M.H., Xu, S. and Vasileiou, S., 2025. Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells. Science Advances, 11(2), p.eadq8114. https://www.science.org/doi/full/10.1126/sciadv.adq8114  

Landi, D., Navai, S.A., Brock, R.M., Fousek, K., Nawas, Z., Sanber, K., Chauvin-Fleurence, C., Bhat, R.R., Xu, S., Krishnamurthy, P. and Choe, M., 2025. A checkpoint reversal receptor mediates bipartite activation and enhances CAR T-cell function. Cancer Research Communications, 5(3), pp.527-548. https://aacrjournals.org/cancerrescommun/article/5/3/527/754500

Serobyan, V., Kontarakis, Z., El-Brolosy, M.A., Welker, J.M., Tolstenkov, O., Saadeldein, A.M., Retzer, N., Gottschalk, A., Wehman, A.M. and Stainier, D.Y., 2020. Transcriptional adaptation in Caenorhabditis elegans. Elife, 9, p.e50014. https://elifesciences.org/articles/50014

Key awards

MSc Scholarship, University of Eastern Finland.

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