Dr Ali Shaib
Group Leader at University Medicine Göttingen
Dr Ali Shaib
Dr Ali Shaib
About
Shaib is a Senior Researcher in the Department of Professor Silvio Rizzoli, where he is also a Group Leader. He holds a PhD in Neuroscience from the University of Saarland.
Current research
Shaib develops a new imaging technology called ONE Microscopy, that allows a one nanometre resolution or better using conventional, inexpensive microscopes. The Shaib group is primarily focused on understanding liquid-liquid phase separation mechanisms, developing diagnostic tools for human neurological diseases, and looking at the shapes of single protein molecules in the of context disease progression.
Future research vision
Shaib and this team aim to achieve a technology that bridges the gap between light microscopy and Cryo-EM. They are currently invested in realising a dream where any lab in any country regardless of their funding state can observe protein structures at an Ångström-resolution using ONE microscopy. To achieve this, they are currently working on designing new expansion chemistry, enhancing the underlying optics, expanding their expertise by adding new members to the team that will focus on solutions that deploy AI.
Key publications

Saal, K A et al. Heat Denaturation Enables Multicolor X10-STED Microscopy. Scientific.Reports, 2023.

Elizarova, S et al. A Fluorescent Nanosensor Paint Detects Dopamine Release at Axonal Varicosities with High Spatiotemporal Resolution. PNAS, 2022.

Rhee, H J et al. An Autaptic Culture System for Standardized Analysis of iPSC-Derived Human Neurons. Cell Reports, 2019.

Shaib, A H et al. Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons. Frontiers in Cellular Neuroscience, 2018.

Bost, A et al. Large Dense-Core Vesicle Exocytosis from Mouse Dorsal Root Ganglion Neurons is Regulated by Neuropeptide Y. Neuroscience, 2017.

Key awards

PhD Scholarship, German Research Council (DFG).

[Declined] PhD Scholarship to study at the University of Pierre et Marie Curie, Prime Minister of Lebanon.

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